Equal randomization: several treatments more effective in distinctive signatures (cfr scen 7)
| signature | var | Other | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| all | param | scale = 0.024, shape = 1.3 | scale = 0.021, shape = 1.3 | scale = 0.023, shape = 1.3 | scale = 0.025, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 43.8, median = 35.8 | mean = 39.3, median = 32.1 | mean = 37.4, median = 30.6 | |
| effect | af = 1, hr = 1 | af = 1.12, hr = 0.86 | af = 1.01, hr = 0.99 | af = 0.96, hr = 1.06 | |
| TP53- | param | scale = 0.024, shape = 1.3 | scale = 0.014, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.025, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 66.5, median = 54.4 | mean = 37.8, median = 30.9 | mean = 37.7, median = 30.8 | |
| effect | af = 1, hr = 1 | af = 1.7, hr = 0.5 | af = 0.97, hr = 1.04 | af = 0.96, hr = 1.05 | |
| TP53+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.022, shape = 1.3 | scale = 0.025, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 41.3, median = 33.8 | mean = 37.1, median = 30.3 | |
| effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.06, hr = 0.93 | af = 0.95, hr = 1.07 | |
| DRD+ | param | scale = 0.024, shape = 1.3 | scale = 0.021, shape = 1.3 | scale = 0.021, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 44.5, median = 36.4 | mean = 43, median = 35.1 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 1.14, hr = 0.84 | af = 1.1, hr = 0.88 | af = 1.9, hr = 0.43 | |
| TEfus+ | param | scale = 0.024, shape = 1.3 | scale = 0.022, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.023, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 41.2, median = 33.7 | mean = 70.5, median = 57.5 | mean = 39.9, median = 32.6 | |
| effect | af = 1, hr = 1 | af = 1.06, hr = 0.93 | af = 1.8, hr = 0.46 | af = 1.02, hr = 0.97 |
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| — | param | scale = 0.024, shape = 1.3 | scale = 0.014, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.029, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 66.5, median = 54.4 | mean = 31.9, median = 26.1 | mean = 31.9, median = 26.1 | |
| effect | af = 1, hr = 1 | af = 1.7, hr = 0.5 | af = 0.82, hr = 1.3 | af = 0.82, hr = 1.3 | |
| –+ | param | scale = 0.024, shape = 1.3 | scale = 0.014, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.029, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 66.5, median = 54.4 | mean = 70.5, median = 57.5 | mean = 31.9, median = 26.1 | |
| effect | af = 1, hr = 1 | af = 1.7, hr = 0.5 | af = 1.8, hr = 0.46 | af = 0.82, hr = 1.3 | |
| -+- | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.029, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 31.9, median = 26.1 | mean = 31.9, median = 26.1 | |
| effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.82, hr = 1.3 | af = 0.82, hr = 1.3 | |
| -++ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.029, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 70.5, median = 57.5 | mean = 31.9, median = 26.1 | |
| effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.8, hr = 0.46 | af = 0.82, hr = 1.3 | |
| +– | param | scale = 0.024, shape = 1.3 | scale = 0.014, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 66.5, median = 54.4 | mean = 31.9, median = 26.1 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 1.7, hr = 0.5 | af = 0.82, hr = 1.3 | af = 1.9, hr = 0.43 | |
| +-+ | param | scale = 0.024, shape = 1.3 | scale = 0.014, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 66.5, median = 54.4 | mean = 70.5, median = 57.5 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 1.7, hr = 0.5 | af = 1.8, hr = 0.46 | af = 1.9, hr = 0.43 | |
| ++- | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 31.9, median = 26.1 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.82, hr = 1.3 | af = 1.9, hr = 0.43 | |
| +++ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 70.5, median = 57.5 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.8, hr = 0.46 | af = 1.9, hr = 0.43 |
|
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The overall error was 0.04.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Niraparib
0.004 0.034 0.002
The overall power was 0.8.
The corresponding power separate for the different treatments were:
Hormone_therapies Taxel_therapies Niraparib
0.326 0.398 0.480
| signature | var | Control | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| all | graduation | 0 | 4 | 3 | 0 |
| futility | 0 | 5 | 13 | 11 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 532 (480, 591) | 344 (252, 464) | 434 (273, 539) | 447 (266, 537) | |
| n_unique | 532 (480, 591) | 344 (252, 464) | 434 (273, 539) | 447 (266, 537) | |
| time_trial | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | |
| time_stop | NA (NA, NA) | 16 (9, 29) | 15 (10, 24) | 12 (6, 26) | |
| post_p | NA (NA, NA) | 0.96 (0.69, 1) | 0.42 (0.06, 0.84) | 0.14 (0.01, 0.59) | |
| rate | 0.019 (0.017, 0.021) | 0.016 (0.014, 0.018) | 0.02 (0.018, 0.022) | 0.021 (0.019, 0.023) | |
| TP53- | graduation | 0 | 163 | 0 | 0 |
| futility | 0 | 3 | 182 | 137 | |
| max_n | 0 | 75 | 65 | 73 | |
| n | 286 (249, 328) | 236 (160, 302) | 236 (66, 301) | 242 (68, 302) | |
| n_unique | 286 (249, 328) | 236 (160, 302) | 236 (66, 301) | 242 (68, 302) | |
| time_trial | 60 (60, 60) | 60 (38, 60) | 60 (16, 60) | 60 (18, 60) | |
| time_stop | NA (NA, NA) | 43 (31, 56) | 21 (13, 40) | 20 (13, 32) | |
| post_p | NA (NA, NA) | 1 (0.96, 1) | 0.08 (0, 0.39) | 0.05 (0, 0.37) | |
| rate | 0.017 (0.015, 0.019) | 0.011 (0.009, 0.013) | 0.021 (0.018, 0.024) | 0.021 (0.019, 0.025) | |
| TP53+ | graduation | 0 | 0 | 32 | 5 |
| futility | 0 | 383 | 26 | 34 | |
| max_n | 0 | 0 | 16 | 15 | |
| n | 246 (208, 286) | 100 (53, 206) | 221 (143, 272) | 215 (134, 267) | |
| n_unique | 246 (208, 286) | 100 (53, 206) | 221 (143, 272) | 215 (134, 267) | |
| time_trial | 60 (60, 60) | 30 (16, 60) | 60 (50, 60) | 60 (60, 60) | |
| time_stop | NA (NA, NA) | 24 (15, 47) | 32 (15, 50) | 21 (17, 31) | |
| post_p | NA (NA, NA) | 0.05 (0, 0.34) | 0.89 (0.47, 0.99) | 0.58 (0.13, 0.93) | |
| rate | 0.022 (0.019, 0.024) | 0.029 (0.024, 0.034) | 0.019 (0.016, 0.022) | 0.021 (0.019, 0.024) | |
| DRD+ | graduation | 0 | 3 | 3 | 240 |
| futility | 0 | 90 | 86 | 4 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 148 (124, 175) | 92 (54, 138) | 117 (53, 159) | 100 (62, 152) | |
| n_unique | 148 (124, 175) | 92 (54, 138) | 117 (53, 159) | 100 (62, 152) | |
| time_trial | 60 (60, 60) | 60 (30, 60) | 60 (34, 60) | 60 (37, 60) | |
| time_stop | NA (NA, NA) | 30 (23, 48) | 30 (23, 48) | 45 (33, 57) | |
| post_p | NA (NA, NA) | 0.71 (0.26, 0.96) | 0.51 (0.12, 0.89) | 1 (0.92, 1) | |
| rate | 0.018 (0.015, 0.021) | 0.016 (0.013, 0.02) | 0.018 (0.014, 0.021) | 0.01 (0.008, 0.012) | |
| TEfus+ | graduation | 0 | 1 | 199 | 0 |
| futility | 0 | 184 | 8 | 130 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 200 (166, 236) | 110 (59, 176) | 147 (94, 209) | 164 (55, 213) | |
| n_unique | 200 (166, 236) | 110 (59, 176) | 147 (94, 209) | 164 (55, 213) | |
| time_trial | 60 (60, 60) | 60 (22, 60) | 60 (38, 60) | 60 (22, 60) | |
| time_stop | NA (NA, NA) | 29 (19, 48) | 46 (33, 57) | 24 (18, 44) | |
| post_p | NA (NA, NA) | 0.31 (0.03, 0.79) | 0.99 (0.88, 1) | 0.11 (0.01, 0.49) | |
| rate | 0.016 (0.014, 0.018) | 0.018 (0.014, 0.022) | 0.01 (0.008, 0.013) | 0.02 (0.017, 0.023) |
| subtype | var | Control | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| — | graduation | 0 | 172 | 188 | 143 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 75 | 65 | 73 | |
| n | 155 (126, 186) | 140 (84, 173) | 131 (36, 168) | 138 (38, 173) | |
| n_unique | 155 (126, 186) | 140 (84, 173) | 131 (36, 168) | 138 (38, 173) | |
| post_p | NA (NA, NA) | 1 (0.96, 1) | 0.03 (0, 0.25) | 0.02 (0, 0.2) | |
| rate | 0.019 (0.016, 0.022) | 0.011 (0.009, 0.013) | 0.027 (0.023, 0.032) | 0.027 (0.023, 0.032) | |
| –+ | graduation | 0 | 326 | 342 | 219 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 73 | 59 | 73 | |
| n | 48 (35, 63) | 34 (15, 52) | 33 (10, 53) | 39 (11, 58) | |
| n_unique | 48 (35, 63) | 34 (15, 52) | 33 (10, 53) | 39 (11, 58) | |
| post_p | NA (NA, NA) | 0.7 (0.32, 0.95) | 0.77 (0.37, 0.96) | 0.02 (0, 0.17) | |
| rate | 0.013 (0.009, 0.019) | 0.011 (0.007, 0.017) | 0.01 (0.006, 0.015) | 0.028 (0.02, 0.039) | |
| -+- | graduation | 0 | 390 | 69 | 48 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 16 | 15 | |
| n | 101 (82, 124) | 44 (22, 91) | 96 (62, 118) | 97 (69, 117) | |
| n_unique | 101 (82, 124) | 44 (22, 91) | 96 (62, 118) | 97 (69, 117) | |
| post_p | NA (NA, NA) | 0.36 (0.06, 0.79) | 0.34 (0.06, 0.8) | 0.38 (0.06, 0.83) | |
| rate | 0.025 (0.021, 0.029) | 0.029 (0.023, 0.036) | 0.027 (0.023, 0.033) | 0.027 (0.022, 0.031) | |
| -++ | graduation | 0 | 429 | 247 | 154 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 15 | 15 | |
| n | 78 (59, 100) | 28 (16, 65) | 67 (30, 91) | 70 (22, 92) | |
| n_unique | 78 (59, 100) | 28 (16, 65) | 67 (30, 91) | 70 (22, 92) | |
| post_p | NA (NA, NA) | 0.08 (0.01, 0.38) | 0.98 (0.81, 1) | 0.07 (0, 0.37) | |
| rate | 0.018 (0.015, 0.023) | 0.029 (0.023, 0.037) | 0.01 (0.007, 0.014) | 0.027 (0.021, 0.034) | |
| +– | graduation | 0 | 246 | 232 | 324 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 73 | 65 | 62 | |
| n | 42 (31, 54) | 35 (17, 52) | 33 (9, 49) | 30 (10, 47) | |
| n_unique | 42 (31, 54) | 35 (17, 52) | 33 (9, 49) | 30 (10, 47) | |
| post_p | NA (NA, NA) | 0.87 (0.51, 0.99) | 0.1 (0.01, 0.38) | 0.9 (0.57, 0.99) | |
| rate | 0.018 (0.013, 0.024) | 0.011 (0.007, 0.017) | 0.027 (0.02, 0.038) | 0.01 (0.006, 0.016) | |
| +-+ | graduation | 0 | 370 | 375 | 383 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 71 | 59 | 62 | |
| n | 40 (27, 54) | 27 (12, 49) | 26 (8, 47) | 25 (9, 46) | |
| n_unique | 40 (27, 54) | 27 (12, 49) | 26 (8, 47) | 25 (9, 46) | |
| post_p | NA (NA, NA) | 0.59 (0.23, 0.88) | 0.63 (0.28, 0.92) | 0.66 (0.29, 0.92) | |
| rate | 0.013 (0.009, 0.018) | 0.011 (0.007, 0.016) | 0.01 (0.006, 0.017) | 0.01 (0.006, 0.016) | |
| ++- | graduation | 0 | 403 | 146 | 274 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 16 | 13 | |
| n | 32 (23, 44) | 12 (6, 32) | 29 (12, 41) | 27 (12, 38) | |
| n_unique | 32 (23, 44) | 12 (6, 32) | 29 (12, 41) | 27 (12, 38) | |
| post_p | NA (NA, NA) | 0.33 (0.08, 0.7) | 0.35 (0.07, 0.71) | 0.98 (0.84, 1) | |
| rate | 0.025 (0.018, 0.033) | 0.029 (0.02, 0.045) | 0.027 (0.019, 0.038) | 0.01 (0.006, 0.015) | |
| +++ | graduation | 0 | 439 | 305 | 355 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 15 | 13 | |
| n | 32 (21, 43) | 12 (6, 29) | 27 (10, 43) | 22 (9, 40) | |
| n_unique | 32 (21, 43) | 12 (6, 29) | 27 (10, 43) | 22 (9, 40) | |
| post_p | NA (NA, NA) | 0.15 (0.02, 0.44) | 0.86 (0.53, 0.98) | 0.86 (0.54, 0.98) | |
| rate | 0.018 (0.013, 0.025) | 0.028 (0.019, 0.045) | 0.01 (0.006, 0.017) | 0.01 (0.006, 0.016) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|
| all | count | 4 | 3 | |
| time_stop | 24 (18, 35) | 24 (20, 25) | ||
| n_trt | 170 (132, 235) | 189 (145, 196) | ||
| n_control | 180 (145, 306) | 164 (155, 192) | ||
| post_p | 1 (0.96, 1) | 0.98 (0.9, 1) | ||
| order | 1 (1, 1.7) | 1 (1, 1.8) | ||
| TP53- | count | 163 | ||
| time_stop | 43 (31, 56) | |||
| n_trt | 197 (137, 266) | |||
| n_control | 202 (141, 280) | |||
| post_p | 1 (0.98, 1) | |||
| order | 1 (1, 2) | |||
| TP53+ | count | 32 | 5 | |
| time_stop | 42 (28, 58) | 34 (21, 41) | ||
| n_trt | 164 (96, 225) | 134 (71, 156) | ||
| n_control | 160 (98, 222) | 151 (68, 173) | ||
| post_p | 0.99 (0.93, 1) | 0.98 (0.97, 0.99) | ||
| order | 1 (1, 2) | 1 (1, 2.2) | ||
| DRD+ | count | 3 | 3 | 240 |
| time_stop | 52 (37, 58) | 50 (48, 56) | 45 (34, 57) | |
| n_trt | 57 (57, 111) | 123 (122, 140) | 98 (64, 141) | |
| n_control | 131 (90, 144) | 110 (107, 138) | 111 (79, 149) | |
| post_p | 0.99 (0.96, 1) | 0.98 (0.96, 0.99) | 1 (0.98, 1) | |
| order | 2 (1.2, 4.4) | 3 (1.4, 3.8) | 1 (1, 2) | |
| TEfus+ | count | 1 | 199 | |
| time_stop | 22 (22, 22) | 46 (34, 57) | ||
| n_trt | 53 (53, 53) | 137 (92, 187) | ||
| n_control | 73 (73, 73) | 154 (107, 198) | ||
| post_p | 1 (1, 1) | 1 (0.96, 1) | ||
| order | 2 (2, 2) | 1 (1, 2) |
| signature | var | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|
| all | count | 5 | 13 | 11 |
| time_stop | 10 (8, 18) | 14 (10, 21) | 12 (6, 26) | |
| n_trt | 77 (61, 117) | 95 (76, 136) | 85 (53, 156) | |
| n_control | 85 (61, 151) | 106 (69, 165) | 76 (48, 245) | |
| post_p | 0.07 (0.05, 0.15) | 0.08 (0.03, 0.21) | 0.19 (0.03, 0.26) | |
| order | 1 (1, 1.6) | 1 (1, 2.8) | 1 (1, 4) | |
| TP53- | count | 3 | 182 | 137 |
| time_stop | 17 (14, 20) | 21 (13, 40) | 20 (13, 32) | |
| n_trt | 82 (68, 84) | 83 (54, 183) | 78 (56, 141) | |
| n_control | 72 (58, 97) | 88 (51, 188) | 84 (50, 145) | |
| post_p | 0.23 (0.15, 0.24) | 0.12 (0.02, 0.26) | 0.13 (0.02, 0.24) | |
| order | 1 (1, 2.6) | 2 (1, 3) | 1 (1, 3) | |
| TP53+ | count | 383 | 26 | 34 |
| time_stop | 24 (15, 47) | 18 (14, 38) | 21 (16, 27) | |
| n_trt | 82 (52, 161) | 56 (50, 108) | 69 (50, 92) | |
| n_control | 82 (48, 173) | 63 (40, 124) | 76 (54, 104) | |
| post_p | 0.12 (0.03, 0.26) | 0.18 (0.1, 0.26) | 0.17 (0.04, 0.27) | |
| order | 2 (1, 3) | 1 (1, 4) | 1 (1, 3) | |
| DRD+ | count | 90 | 86 | 4 |
| time_stop | 29 (23, 47) | 30 (23, 48) | 25 (23, 27) | |
| n_trt | 56 (50, 95) | 62 (51, 92) | 54 (51, 57) | |
| n_control | 69 (48, 119) | 73 (50, 122) | 48 (44, 54) | |
| post_p | 0.17 (0.06, 0.28) | 0.14 (0.04, 0.27) | 0.24 (0.12, 0.29) | |
| order | 3 (1, 4.1) | 3 (1, 4) | 2 (1.3, 4.1) | |
| TEfus+ | count | 184 | 8 | 130 |
| time_stop | 29 (19, 48) | 23 (16, 33) | 24 (18, 44) | |
| n_trt | 78 (52, 126) | 60 (51, 84) | 66 (51, 125) | |
| n_control | 82 (53, 163) | 68 (42, 96) | 74 (50, 137) | |
| post_p | 0.14 (0.03, 0.26) | 0.16 (0.1, 0.25) | 0.11 (0.01, 0.25) | |
| order | 2 (1, 4) | 2.5 (1, 4.9) | 2 (1, 4) |
| signature | treatment | var | — | –+ | -+- | -++ | +– | +-+ | ++- | +++ |
|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| time | 24 (18, 35) | 24 (18, 35) | 24 (18, 35) | 24 (18, 35) | 24 (18, 35) | 24 (18, 35) | 24 (18, 35) | 24 (18, 35) | ||
| n | 50 (32, 89) | 12 (11, 13) | 36 (29, 55) | 20 (20, 23) | 18 (9, 23) | 11 (11, 12) | 12 (9, 15) | 9 (8, 10) | ||
| post_p | 0.91 (0.69, 1) | 0.67 (0.65, 0.73) | 0.72 (0.66, 0.82) | 0.63 (0.58, 0.77) | 0.56 (0.56, 0.61) | 0.58 (0.56, 0.67) | 0.6 (0.58, 0.61) | 0.59 (0.55, 0.75) | ||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.008 (0.006, 0.01) | 0.004 (0, 0.01) | 0.015 (0.009, 0.026) | 0.012 (0.005, 0.016) | 0.007 (0.002, 0.01) | 0 (0, 0.005) | 0.016 (0.004, 0.025) | 0.004 (0, 0.009) | ||
| Taxel_therapies | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |
| time | 24 (20, 25) | 24 (20, 25) | 24 (20, 25) | 24 (20, 25) | 24 (20, 25) | 24 (20, 25) | 24 (20, 25) | 24 (20, 25) | ||
| n | 55 (41, 66) | 17 (11, 18) | 33 (31, 45) | 22 (19, 26) | 15 (8, 15) | 13 (10, 18) | 8 (8, 12) | 10 (9, 11) | ||
| post_p | 0.6 (0.59, 0.63) | 0.59 (0.57, 0.69) | 0.79 (0.62, 0.9) | 0.76 (0.65, 0.9) | 0.56 (0.56, 0.57) | 0.6 (0.6, 0.63) | 0.6 (0.57, 0.64) | 0.63 (0.59, 0.67) | ||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.015 (0.009, 0.016) | 0.008 (0.002, 0.011) | 0.017 (0.011, 0.028) | 0.005 (0.001, 0.007) | 0.005 (0.001, 0.005) | 0.004 (0.001, 0.01) | 0.012 (0.01, 0.013) | 0 (0, 0.01) | ||
| TP53- | Hormone_therapies | count | 163 | 163 | 163 | 163 | ||||
| time | 43 (31, 56) | 43 (31, 56) | 43 (31, 56) | 43 (31, 56) | ||||||
| n | 109 (71, 146) | 31 (19, 47) | 27 (18, 42) | 28 (16, 44) | ||||||
| post_p | 0.99 (0.87, 1) | 0.8 (0.71, 0.93) | 0.8 (0.71, 0.95) | 0.74 (0.7, 0.85) | ||||||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.01 (0.007, 0.013) | 0.008 (0.004, 0.011) | 0.009 (0.004, 0.013) | 0.007 (0.002, 0.011) | ||||||
| TP53+ | Taxel_therapies | count | 32 | 32 | 32 | 32 | ||||
| time | 42 (28, 58) | 42 (28, 58) | 42 (28, 58) | 42 (28, 58) | ||||||
| n | 67 (40, 91) | 50 (26, 71) | 20 (11, 29) | 20 (13, 28) | ||||||
| post_p | 0.79 (0.72, 0.9) | 0.91 (0.74, 0.99) | 0.73 (0.7, 0.8) | 0.77 (0.7, 0.94) | ||||||
| r_prob | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.021 (0.015, 0.024) | 0.01 (0.003, 0.013) | 0.017 (0.007, 0.026) | 0.007 (0, 0.011) | ||||||
| Niraparib | count | 5 | 5 | 5 | 5 | |||||
| time | 34 (21, 41) | 34 (21, 41) | 34 (21, 41) | 34 (21, 41) | ||||||
| n | 53 (27, 75) | 27 (24, 52) | 15 (9, 25) | 11 (7, 25) | ||||||
| post_p | 0.74 (0.71, 0.88) | 0.82 (0.77, 0.88) | 0.74 (0.64, 0.92) | 0.78 (0.62, 0.83) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.019 (0.009, 0.023) | 0.011 (0.003, 0.019) | 0.007 (0, 0.013) | 0 (0, 0.005) | ||||||
| DRD+ | Hormone_therapies | count | 3 | 3 | 3 | 3 | ||||
| time | 52 (37, 58) | 52 (37, 58) | 52 (37, 58) | 52 (37, 58) | ||||||
| n | 22 (19, 48) | 19 (13, 19) | 15 (8, 34) | 13 (10, 14) | ||||||
| post_p | 0.72 (0.72, 0.93) | 0.75 (0.73, 0.81) | 0.77 (0.66, 0.83) | 0.74 (0.71, 0.81) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.011 (0.005, 0.013) | 0.01 (0.002, 0.01) | 0.023 (0.005, 0.024) | 0.01 (0.007, 0.014) | ||||||
| Taxel_therapies | count | 3 | 3 | 3 | 3 | |||||
| time | 50 (48, 56) | 50 (48, 56) | 50 (48, 56) | 50 (48, 56) | ||||||
| n | 36 (22, 47) | 40 (28, 46) | 29 (25, 33) | 26 (24, 33) | ||||||
| post_p | 0.79 (0.72, 0.87) | 0.81 (0.77, 0.82) | 0.72 (0.71, 0.81) | 0.89 (0.83, 0.94) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.013 (0.013, 0.017) | 0.008 (0.008, 0.009) | 0.018 (0.017, 0.02) | 0.01 (0.006, 0.012) | ||||||
| Niraparib | count | 240 | 240 | 240 | 240 | |||||
| time | 45 (34, 57) | 45 (34, 57) | 45 (34, 57) | 45 (34, 57) | ||||||
| n | 28 (12, 42) | 28 (10, 45) | 22 (12, 34) | 22 (11, 34) | ||||||
| post_p | 0.83 (0.72, 0.98) | 0.74 (0.7, 0.87) | 0.93 (0.75, 1) | 0.8 (0.71, 0.96) | ||||||
| r_prob | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.008 (0.003, 0.013) | 0.007 (0.003, 0.01) | 0.008 (0.004, 0.013) | 0.007 (0.002, 0.012) | ||||||
| TEfus+ | Hormone_therapies | count | 1 | 1 | 1 | 1 | ||||
| time | 22 (22, 22) | 22 (22, 22) | 22 (22, 22) | 22 (22, 22) | ||||||
| n | 13 (13, 13) | 20 (20, 20) | 11 (11, 11) | 9 (9, 9) | ||||||
| post_p | 0.76 (0.76, 0.76) | 0.72 (0.72, 0.72) | 0.72 (0.72, 0.72) | 0.63 (0.63, 0.63) | ||||||
| r_prob | 0.19 (0.19, 0.19) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0 (0, 0) | 0.01 (0.01, 0.01) | 0 (0, 0) | 0 (0, 0) | ||||||
| Taxel_therapies | count | 199 | 199 | 199 | 199 | |||||
| time | 46 (34, 57) | 46 (34, 57) | 46 (34, 57) | 46 (34, 57) | ||||||
| n | 34 (15, 47) | 55 (32, 79) | 29 (12, 45) | 22 (12, 35) | ||||||
| post_p | 0.81 (0.71, 0.96) | 0.96 (0.76, 1) | 0.74 (0.7, 0.91) | 0.8 (0.71, 0.95) | ||||||
| r_prob | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.008 (0.004, 0.012) | 0.009 (0.005, 0.013) | 0.007 (0.003, 0.01) | 0.008 (0.003, 0.013) |
| signature | treatment | var | — | –+ | -+- | -++ | +– | +-+ | ++- | +++ |
|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| time | 10 (8, 18) | 10 (8, 18) | 10 (8, 18) | 10 (8, 18) | 10 (8, 18) | 10 (8, 18) | 10 (8, 18) | 10 (8, 18) | ||
| n | 24 (16, 39) | 8 (6, 11) | 16 (14, 23) | 12 (10, 16) | 4 (2, 10) | 5 (2, 10) | 4 (1, 7) | 4 (2, 6) | ||
| post_p | 0.45 (0.39, 0.5) | 0.41 (0.36, 0.44) | 0.42 (0.29, 0.46) | 0.43 (0.33, 0.45) | 0.49 (0.34, 0.5) | 0.48 (0.39, 0.49) | 0.45 (0.44, 0.47) | 0.44 (0.39, 0.49) | ||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.018 (0.016, 0.018) | 0.022 (0.015, 0.037) | 0.025 (0.022, 0.035) | 0.028 (0.016, 0.057) | 0 (0, 0.04) | 0.02 (0.004, 0.029) | 0.027 (0.01, 0.084) | 0.025 (0, 0.07) | ||
| Taxel_therapies | count | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | |
| time | 14 (10, 21) | 14 (10, 21) | 14 (10, 21) | 14 (10, 21) | 14 (10, 21) | 14 (10, 21) | 14 (10, 21) | 14 (10, 21) | ||
| n | 29 (24, 34) | 10 (5, 16) | 15 (12, 34) | 13 (9, 28) | 8 (5, 11) | 10 (5, 18) | 6 (2, 8) | 5 (1, 12) | ||
| post_p | 0.35 (0.19, 0.42) | 0.45 (0.42, 0.49) | 0.44 (0.27, 0.48) | 0.45 (0.36, 0.47) | 0.45 (0.31, 0.5) | 0.48 (0.41, 0.49) | 0.44 (0.28, 0.49) | 0.46 (0.37, 0.49) | ||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.02 (0.014, 0.028) | 0.013 (0, 0.029) | 0.026 (0.013, 0.035) | 0.016 (0.009, 0.039) | 0.015 (0, 0.043) | 0 (0, 0.024) | 0.049 (0.006, 0.139) | 0.01 (0, 0.046) | ||
| Niraparib | count | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | |
| time | 12 (6, 26) | 12 (6, 26) | 12 (6, 26) | 12 (6, 26) | 12 (6, 26) | 12 (6, 26) | 12 (6, 26) | 12 (6, 26) | ||
| n | 24 (18, 37) | 6 (4, 12) | 16 (12, 45) | 12 (6, 25) | 6 (1, 9) | 7 (2, 10) | 4 (2, 14) | 5 (1, 10) | ||
| post_p | 0.34 (0.25, 0.43) | 0.43 (0.28, 0.48) | 0.37 (0.14, 0.46) | 0.46 (0.32, 0.49) | 0.48 (0.34, 0.5) | 0.48 (0.4, 0.49) | 0.48 (0.42, 0.5) | 0.49 (0.47, 0.5) | ||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||
| rate | 0.023 (0.014, 0.05) | 0.024 (0, 0.052) | 0.031 (0.021, 0.061) | 0.02 (0, 0.032) | 0 (0, 0.028) | 0.006 (0, 0.017) | 0.017 (0, 0.027) | 0.006 (0, 0.02) | ||
| TP53- | Hormone_therapies | count | 3 | 3 | 3 | 3 | ||||
| time | 17 (14, 20) | 17 (14, 20) | 17 (14, 20) | 17 (14, 20) | ||||||
| n | 36 (34, 46) | 11 (11, 16) | 11 (9, 13) | 14 (12, 15) | ||||||
| post_p | 0.42 (0.36, 0.44) | 0.48 (0.35, 0.48) | 0.43 (0.41, 0.46) | 0.4 (0.36, 0.46) | ||||||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.016 (0.013, 0.021) | 0.019 (0.009, 0.021) | 0.015 (0.011, 0.026) | 0.012 (0.002, 0.013) | ||||||
| Taxel_therapies | count | 182 | 182 | 182 | 182 | |||||
| time | 21 (13, 40) | 21 (13, 40) | 21 (13, 40) | 21 (13, 40) | ||||||
| n | 46 (28, 100) | 14 (7, 31) | 13 (7, 24) | 12 (7, 26) | ||||||
| post_p | 0.26 (0.04, 0.45) | 0.46 (0.37, 0.5) | 0.38 (0.18, 0.47) | 0.45 (0.31, 0.49) | ||||||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.023 (0.016, 0.03) | 0.014 (0.008, 0.028) | 0.024 (0.014, 0.047) | 0.013 (0, 0.025) | ||||||
| Niraparib | count | 137 | 137 | 137 | 137 | |||||
| time | 20 (13, 32) | 20 (13, 32) | 20 (13, 32) | 20 (13, 32) | ||||||
| n | 44 (30, 79) | 14 (8, 25) | 12 (7, 22) | 11 (6, 22) | ||||||
| post_p | 0.27 (0.07, 0.43) | 0.37 (0.11, 0.48) | 0.46 (0.38, 0.5) | 0.46 (0.37, 0.5) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.023 (0.016, 0.029) | 0.026 (0.012, 0.042) | 0.014 (0.006, 0.027) | 0.013 (0, 0.025) | ||||||
| TP53+ | Hormone_therapies | count | 383 | 383 | 383 | 383 | ||||
| time | 24 (15, 47) | 24 (15, 47) | 24 (15, 47) | 24 (15, 47) | ||||||
| n | 35 (21, 70) | 25 (15, 50) | 11 (5, 23) | 11 (6, 22) | ||||||
| post_p | 0.37 (0.15, 0.48) | 0.34 (0.05, 0.47) | 0.43 (0.24, 0.49) | 0.39 (0.15, 0.48) | ||||||
| r_prob | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.026 (0.019, 0.034) | 0.024 (0.016, 0.035) | 0.025 (0.014, 0.047) | 0.024 (0.013, 0.041) | ||||||
| Taxel_therapies | count | 26 | 26 | 26 | 26 | |||||
| time | 18 (14, 38) | 18 (14, 38) | 18 (14, 38) | 18 (14, 38) | ||||||
| n | 24 (20, 48) | 18 (12, 34) | 9 (6, 15) | 9 (4, 18) | ||||||
| post_p | 0.36 (0.19, 0.47) | 0.46 (0.37, 0.49) | 0.41 (0.3, 0.47) | 0.45 (0.36, 0.49) | ||||||
| r_prob | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.028 (0.021, 0.04) | 0.016 (0.007, 0.02) | 0.03 (0.014, 0.052) | 0.02 (0.004, 0.038) | ||||||
| Niraparib | count | 34 | 34 | 34 | 34 | |||||
| time | 21 (16, 27) | 21 (16, 27) | 21 (16, 27) | 21 (16, 27) | ||||||
| n | 30 (21, 40) | 22 (17, 28) | 9 (5, 14) | 9 (4, 12) | ||||||
| post_p | 0.31 (0.16, 0.48) | 0.35 (0.1, 0.48) | 0.46 (0.38, 0.49) | 0.47 (0.4, 0.49) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.028 (0.02, 0.037) | 0.026 (0.017, 0.038) | 0.02 (0.009, 0.035) | 0.014 (0.003, 0.028) | ||||||
| DRD+ | Hormone_therapies | count | 90 | 90 | 90 | 90 | ||||
| time | 29 (23, 47) | 29 (23, 47) | 29 (23, 47) | 29 (23, 47) | ||||||
| n | 20 (12, 35) | 19 (12, 32) | 11 (6, 17) | 11 (6, 17) | ||||||
| post_p | 0.44 (0.29, 0.49) | 0.45 (0.3, 0.49) | 0.36 (0.17, 0.49) | 0.26 (0.06, 0.46) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.016 (0.01, 0.024) | 0.012 (0.006, 0.02) | 0.029 (0.013, 0.048) | 0.027 (0.014, 0.048) | ||||||
| Taxel_therapies | count | 86 | 86 | 86 | 86 | |||||
| time | 30 (23, 48) | 30 (23, 48) | 30 (23, 48) | 30 (23, 48) | ||||||
| n | 19 (10, 28) | 16 (8, 27) | 15 (8, 24) | 14 (8, 28) | ||||||
| post_p | 0.24 (0.05, 0.44) | 0.44 (0.3, 0.5) | 0.36 (0.15, 0.48) | 0.45 (0.34, 0.49) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.025 (0.014, 0.037) | 0.011 (0.006, 0.02) | 0.028 (0.017, 0.044) | 0.016 (0.008, 0.023) | ||||||
| Niraparib | count | 4 | 4 | 4 | 4 | |||||
| time | 25 (23, 27) | 25 (23, 27) | 25 (23, 27) | 25 (23, 27) | ||||||
| n | 14 (10, 18) | 14 (9, 17) | 14 (8, 19) | 13 (12, 14) | ||||||
| post_p | 0.44 (0.29, 0.48) | 0.48 (0.44, 0.49) | 0.44 (0.42, 0.49) | 0.41 (0.29, 0.46) | ||||||
| r_prob | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.015 (0.011, 0.025) | 0.011 (0.009, 0.018) | 0.014 (0.006, 0.02) | 0.021 (0.017, 0.025) | ||||||
| TEfus+ | Hormone_therapies | count | 184 | 184 | 184 | 184 | ||||
| time | 29 (19, 48) | 29 (19, 48) | 29 (19, 48) | 29 (19, 48) | ||||||
| n | 20 (12, 38) | 26 (17, 41) | 17 (10, 34) | 11 (6, 21) | ||||||
| post_p | 0.44 (0.29, 0.49) | 0.26 (0.04, 0.44) | 0.45 (0.32, 0.49) | 0.36 (0.09, 0.48) | ||||||
| r_prob | 0.19 (0.19, 0.19) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.015 (0.01, 0.022) | 0.025 (0.017, 0.034) | 0.012 (0.007, 0.021) | 0.024 (0.013, 0.04) | ||||||
| Taxel_therapies | count | 8 | 8 | 8 | 8 | |||||
| time | 23 (16, 33) | 23 (16, 33) | 23 (16, 33) | 23 (16, 33) | ||||||
| n | 15 (9, 17) | 24 (17, 33) | 14 (8, 19) | 10 (6, 21) | ||||||
| post_p | 0.48 (0.39, 0.49) | 0.38 (0.23, 0.43) | 0.43 (0.27, 0.48) | 0.45 (0.4, 0.47) | ||||||
| r_prob | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.014 (0.007, 0.02) | 0.017 (0.015, 0.04) | 0.015 (0.008, 0.022) | 0.018 (0.009, 0.034) | ||||||
| Niraparib | count | 130 | 130 | 130 | 130 | |||||
| time | 24 (18, 44) | 24 (18, 44) | 24 (18, 44) | 24 (18, 44) | ||||||
| n | 16 (11, 32) | 28 (18, 52) | 14 (7, 28) | 11 (6, 21) | ||||||
| post_p | 0.3 (0.04, 0.45) | 0.29 (0.07, 0.46) | 0.43 (0.32, 0.49) | 0.46 (0.38, 0.49) | ||||||
| r_prob | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.023 (0.013, 0.041) | 0.025 (0.017, 0.036) | 0.013 (0.007, 0.023) | 0.015 (0.008, 0.024) |